Minimization of the distortion of quadrilateral and hexahedral meshes

En este artículo se presenta un algoritmo para la minimización de la medida de la distorsión definida por Oddy para una malla formada por cuadriláteros o hexaedros. Aunque dicha medida ha sido ampliamente utilizada, su definición original presenta varias propiedades que limitan su utilización en un algoritmo de minimización. Por ejemplo, sólo es válida para cuadriláteros o hexaedros convexos y proporciona un valor infinito de la distorsión en un cuadrilátero en el que tres vértices están alineados. Con el fin de superar estas limitaciones, en este trabajo primero se deduce una interpretación geométrica de la definición original de la medida de la distorsión. Además se demuestra que dicha interpretación es válida tanto para cuadriláteros como para hexaedros. Seguidamente y basándose en dicha interpretación, se desarrolla una medida de la distorsión para cuadriláteros y hexaedros no convexos. Finalmente, se presenta un algoritmo para la minimización de la nueva medida de la distorsión de la malla basado en el método de Newton-Raphson. Es importante resaltar que ambas definiciones coinciden cerca de la solución óptima. Así mismo, se presentan varios ejemplos que confirman la eficiencia del algoritmo desarrollado.Peer Reviewe

Relativistic positioning: four-dimensional numerical approach in Minkowski space-time

We simulate the satellite constellations of two Global Navigation Satellite Systems: Galileo (EU) and GPS (USA). Satellite motions are described in the Schwarzschild space-time produced by an idealized spherically symmetric non rotating Earth. The trajectories are then circumferences centered at the same point as Earth. Photon motions are described in Minkowski space-time, where there is a well known relation, Coll, Ferrando & Morales-Lladosa (2010), between the emission and inertial coordinates of any event. Here, this relation is implemented in a numerical code, which is tested and applied. The first application is a detailed numerical four-dimensional analysis of the so-called emission coordinate region and co-region. In a second application, a GPS (Galileo) satellite is considered as the receiver and its emission coordinates are given by four Galileo (GPS) satellites. The bifurcation problem (double localization) in the positioning of the receiver satellite is then pointed out and discussed in detail.Comment: 16 pages, 9 figures, published (online) in Astrophys. Space Sc

Robust volume mesh generation for non-watertight geometries

Nowadays large part of the time needed to perform a numerical simulation is spent in preprocessing, especially in the geometry cleaning operations and mesh generation. Furthermore, these operations are not easy to automatize because they depend strongly on each geometrical model and they often need human interaction. Many of these operations are needed to obtain a watertight geometry. Even with a clean geometry, classical unstructured meshing methods (like Delaunay or Advancing Front based ones) present critical weak points like the need of a given quality in the boundary mesh or a relatively smooth size transition. These aspects decrease their robustness and imply an extra effort in order to reach the final mesh. Octree based meshers try to relax some of these requirements. In the present work an octree based mesher for unstructured tetrahedra is presented. The proposed mesher ensures the mesh generation avoiding most of the geometry cleaning operations. It is based in the following steps: fit an octree onto the model, refine it following given criteria, apply a tetrahedra pattern to the octree cells and adapt the tetrahedra close to the contours in order to represent accurately the boundary shape. An important and innovative aspect of the proposed algorithm is it ensures the final mesh preserves the topology and the geometric features of the original model. The method uses a Ray Casting based algorithm for the identification of the inner and outer parts of the volumes involved in the model. This technique allows the mesh generation of volumes even with non-watertight boundaries, and also opens the use of the mesher for immersed methods only applying slight modifications to the algorithm. The main advantages of the presented mesher are: robustness, no need for watertight boundaries, independent on the contour mesh quality, preservation of geometrical features (corners and ridges), original geometric topology guaranteed, accurate representation of the contours, valid for immersed methods, and fast performance. A lot of time in the preprocessing part of the numerical simulation is saved thanks to the robustness of the mesher, which allows skipping most of the geometry cleaning operations. A shared memory parallel implementation of the algorithm has been done. The effectiveness of the algorithm and its implementation has been verified by some validation examples.En l'actualitat gran part del temps emprat per córrer una simulació numèrica està dedicat al preprocés, especialment a les operacions de neteja de geometria i generació de malla. A més, aquestes operacions no són fàcils d'automatitzar degut a la seva forta dependència del model geomètric i sovint necessiten d’interacció humana. Moltes d'aquestes operacions són necessàries per aconseguir una definició topológicament hermètica de la geometria. Inclús amb una geometria neta, els mètodes clàssics de mallat (com els basats en Delaunay o avançament frontal) presenten punts febles crítics com la necessitat d'una certa qualitat de les malles de contorn o una transició de mides relativament suau. Aquests aspectes disminueixen la seva robustesa i impliquen un esforç extra a l'hora d'obtenir la malla final. Els mètodes de mallat basats en estructures octree relaxen alguns d'aquests requeriments. En aquest treball es presenta un mallador basat en octree per tetraedres no estructurats. Un dels aspectes claus d'aquest mallador és que garanteix la generació de malla evitant moltes de les operacions de neteja de geometria. Es basa en els següents passos: encaixar un octree al model, refinar-lo seguint certs criteris, aplicar un patró de tetraedres a les cel•les de l'octree i adaptar-los a les zones properes als contorns a fi i efecte de representar acuradament la forma del domini. Un aspecte important i innovador de l'algorisme proposat és que manté la topologia del model a la malla final i preserva les seves característiques geomètriques. El mètode presentat utilitza un algorisme basat en la tècnica Ray Casting per la identificació de les parts interiors i exteriors dels volums del model. Aquesta tècnica permet la generació de malla de volums inclús amb contorns que no tanquen hermèticament, i també obre l’ús del mallador a mètodes “immersed” aplicant només petites modificacions a l'algorisme. Els principals avantatges del mallador presentat són: robustesa, no necessitat de definicions hermètiques dels contorns, independent de la qualitat de la malla de contorn, preservació de característiques geomètriques (cantonades i arestes abruptes), topologia original de la geometria garantida, representació precisa dels contorns, vàlid per mètodes “immersed” i ràpid rendiment. L’ús del mallador estalvia molt de temps en la part del preprocés de la simulació numèrica gràcies a la seva robustesa que permet obviar la majoria d'operacions de neteja de geometria. S'ha dut a terme una implementació paral•lela amb memòria compartida de l'algorisme. L'efectivitat del mateix i la seva implementació ha estat verificada mitjançant exemples de validació

GiD 2008. 4th Conference on advances and applications of GiD

The extended use of simulation programs has leaned on the advances in user-friendly interfaces and in the capability to generate meshes for any generic complex geometry. More than ten years of development have made Gid grow to become one of the more popular pre ans postprocessing systems at international level. The constant dialogue between the GiD development team and the users has guided the development of giD to cover the pre-post needs of many disciplines in science and engineering. Following gthis philosophy, the biannual GiD Conference has become an important forum for discussion and interchange of experiences among the GiD community. This monograph includes the contributions of the participants to the fourth edition of the GiD Conference held in the island of Ibiza from 8-9 May 2008

Minimización de la distorsión de mallas formadas por cuadriláteros o hexaedros

En este artículo se presenta un algoritmo para la minimización de la medida de la distorsión definida por Oddy para una malla formada por cuadriláteros o hexaedros. Aunque dicha medida ha sido ampliamente utilizada, su definición original presenta varias propiedades que limitan su utilización en un algoritmo de minimización. Por ejemplo, sólo es válida para cuadriláteros o hexaedros convexos y proporciona un valor infinito de la distorsión en un cuadrilátero en el que tres vértices están alineados. Con el fin de superar estas limitaciones, en este trabajo primero se deduce una interpretación geométrica de la definición original de la medida de la distorsión. Además se demuestra que dicha interpretación es válida tanto para cuadriláteros como para hexaedros. Seguidamente y basándose en dicha interpretación, se desarrolla una medida de la distorsión para cuadriláteros y hexaedros no convexos. Finalmente, se presenta un algoritmo para la minimización de la nueva medida de la distorsión de la malla basado en el método de Newton-Raphson. Es importante resaltar que ambas definiciones coinciden cerca de la solución óptima. Así mismo, se presentan varios ejemplos que confirman la eficiencia del algoritmo desarrollado.Peer ReviewedPostprint (published version

Scalable system for large unstructured mesh simulation

Dealing with large simulation is a growing challenge. Ideally for the wellparallelized software prepared for high performance, the problem solving capability depends on the available hardware resources. But in practice there are several technical details which reduce the scalability of the system and prevent the effective use of such a software for large problems. In this work we describe solutions implemented in order to obtain a scalable system to solve and visualize large scale problems. The present work is based on Kratos MutliPhysics [1] framework in combination with GiD [2] pre and post processor. The applied techniques are verified by CFD simulation and visualization of a wind tunnel problem with more than 100 millions of elements in our in-hose cluster in CIMNE.Postprint (published version

Toxicity of wine effluents and assessment of a depuration system for their control: assay with tadpoles of Rhinella arenarum (BUFONIDAE)

We evaluated the toxicity of the winery effluent and the efficiency of a symbiotic depuration system by means an experiment with Rhinella arenarum tadpoles. The studied effluent was taken from warehouses during the cleaning season. These effluents subsequently subjected to the purification treatment under evaluation. The effluent samples differentiated into two treatment levels: “raw” where the effluent was evaluated with field conditions and “treated” where the effluent was previously filtered with the symbiotic depuration system. The results of the bioassays compared with the physicochemical parameters determined in the effluent samples. The lethal response had a clear-cut correspondence with the effluent quality assessed utilizing physicochemical parameters. In all cases, dilution of the samples resulted in a significant reduction of their toxicity. It concluded that (a) winery effluents could be harmful to tadpoles of R. arenarum, (b) the symbiotic purification system used to treat wine effluents it would produce a significant reduction in the contaminant levels of the effluent. However, this reduction in contaminant levels does not provide sufficient safety for the release of the effluents into the environment.Fil: Navas Romero, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Herrera Moratta, Mario Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Rodríguez, María Rosa. Universidad Nacional de San Juan. Facultad de Ingeniería; ArgentinaFil: Quiroga, Lorena Beatriz. Universidad Nacional de San Juan. Facultad de Filosofía, Humanidades y Artes. Instituto de Ciencias Básicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Echegaray, Marcelo Eduardo. Universidad Nacional de San Juan. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Sanabria, Eduardo Alfredo. Universidad Nacional de San Juan. Facultad de Filosofía, Humanidades y Artes. Instituto de Ciencias Básicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentin

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1-4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0-8·4) while the total sum of global YLDs increased from 562 million (421-723) to 853 million (642-1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6-9·2) for males and 6·5% (5·4-7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782-3252] per 100 000 in males vs 1400 [1279-1524] per 100 000 in females), transport injuries (3322 [3082-3583] vs 2336 [2154-2535]), and self-harm and interpersonal violence (3265 [2943-3630] vs 5643 [5057-6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field